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Alice Wexler
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Mapping Fate: A Memoir of Family, Risk, and Genetic Research

by Alice Wexler (Author)
4.2 4.2 out of 5 stars 36 ratings
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In Mapping Fate, Alice Wexler tells the story of a family at risk for a hereditary, incurable, fatal disorder: Huntington's disease, once called Huntington's chorea. That her mother died of the disease, that her own chance of inheriting it was fifty-fifty, that her sister and father directed much of the extraordinary biomedical research to find the gene and a cure, make Wexler's story both astonishingly intimate and scientifically compelling.

Alice Wexler's graceful and eloquent account goes beyond the specifics of Huntington's disease to explore the dynamics of family secrets, of living at risk, and the drama and limits of biomedical research. Mapping Fate will be a touchstone for anyone with questions about genetic illness and the possibilites and perils of genetic testing.
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  1. ISBN-10
    0520207416
  2. ISBN-13
    978-0520207417
  3. Publisher
    University of California Press
  4. Publication date
    December 30, 1996
  5. Language
    English
  6. Dimensions
    5.5 x 0.8 x 8.25 inches
  7. Print length
    319 pages
  8. See all details
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Editorial Reviews

From Publishers Weekly

Memoir of a family living under the shadow of the genetically transmitted Huntington's disease, two of whose members become prominent researchers in the quest for a cure.
Copyright 1996 Reed Business Information, Inc.

Review

"["Mapping Fate] deserves a wide audience. Readers interested in the psychological dimensions of illness, especially inherited illness, will find it riveting. . . . [It] is excellent as an introduction to human genetics. . . . I cannot think of another book that contains information about family dynamics, clinical genetics, and bench research in such a readable form."--Roger L. Albin, M. D., "Journal of the American Medical Association

Product details

  • Publisher ‏ : ‎ University of California Press (December 30, 1996)
  • Language ‏ : ‎ English
  • Paperback ‏ : ‎ 319 pages
  • ISBN-10 ‏ : ‎ 0520207416
  • ISBN-13 ‏ : ‎ 978-0520207417
  • Item Weight ‏ : ‎ 1.05 pounds
  • Dimensions ‏ : ‎ 5.5 x 0.8 x 8.25 inches
  • Customer Reviews:
    4.2 4.2 out of 5 stars 36 ratings

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Alice Wexler

Alice Wexler

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Customer reviews

4.2 out of 5 stars
4.2 out of 5
36 global ratings

Top reviews from the United States

bb.blue
5.0 out of 5 stars Information anyone could use!
Reviewed in the United States on December 30, 2011
Verified Purchase
This book is so well written! Anyone who is dealing with this diease personally; or, has a friend or loved one. Who has been recently given this diagnosis. Needs to read, and share this book with others. Discussion about various chapters,will enable anyone to ease into a more personalized diaologue, with their loved ones, as well as being able to understand the diease themselves if they are dealing with the drain of this horrible diease. I would like to be able to afford a copy for many people. Who are wrapped in their ignorance! This book will open anyone's eyes to what a slow twisted dance this diease truly is.
Not to medical. Yet, not "preachy", but highly informative! Read well. Such as a good fiction novel; but, there was no denying that this was about real lives and learning how to adjust,deal with, and live. As best as one can do with the gradual loss of one's physical abliites,and the impact on one's mental health as well.
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Maud H. Chaplin
5.0 out of 5 stars well worth reading
Reviewed in the United States on May 5, 2019
Verified Purchase
Although this book is ostensibly about the role of genetics in disease, its focus is on Huntington's, a hereditary illness, which is crippling of mind and body. The author is unflinching in describing its effect on a family, and she also provides an interesting history of the incidence of the disease itself, for which there is no known cure. Well-written, it is accessible to those with a non-scientific bent as well as those well versed in this field.
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John Nalundasan Riingen of Valencia Parkway
4.0 out of 5 stars In Mapping Fate, Alice Wexler is a very honest ...
Reviewed in the United States on January 30, 2017
Verified Purchase
In Mapping Fate, Alice Wexler is a very honest author who tells about a hereditary brain disorder nobody wants to talk about, and kept as a "family secret", the: Huntington's Disease (HDs), which she and other members of her family are affected. Perhaps she is the first one to write about it.
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Shelley R. Williams
5.0 out of 5 stars Good purchase
Reviewed in the United States on November 2, 2021
Verified Purchase
As described and at a fair price. Arrived on time. Ordered used from a nonprofit (more than words), would order from them again.
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Trudy Chiquillo
3.0 out of 5 stars eye opening
Reviewed in the United States on September 2, 2015
Verified Purchase
I enjoyed most of the book when it was relating the family struggles. For me it got too much into the science aspects and was a little distracted as I did not understand that aspect well.
One person found this helpful
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AmazonReview
5.0 out of 5 stars Amazing book about risk and HD and I learned a lot!
Reviewed in the United States on November 19, 2010
Verified Purchase
I have a friend who has HD in her family and she was going to read this book so I read it too to learn more about HD and how people deal with risk. It was an amazing book. Alice wrote her personal story in addition to providing the scientific info on HD and the gene. I loved the book. In fact, now I'm passing it on to my sister to read.
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Ann Niday Straley
2.0 out of 5 stars Too much techical writing for me
Reviewed in the United States on September 9, 2020
Verified Purchase
This is a book that I would not have selelcted; it was book club choice. I found it highly technical with medical writing and charts. The story line did not resolve as to whether the two daughters were or were not genetically poised to get the disease. Would not recommend unltess one has a medical background or interest in Huntington's Disease.
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uptownrn
5.0 out of 5 stars A beautiful book.
Reviewed in the United States on January 31, 2012
Verified Purchase
Beautifully written this book touches on the Wexlers' own personal story with HD in addition to their quest to find the identifying HD gene. It shed so much light on this disease for me shortly after my father was diagnosed and I was grappling with the issue of whether or not to be tested. If Huntington's Disease touches your life in some way this is a must read.
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Top reviews from other countries

DR.P.S.Mahadevan
4.0 out of 5 stars great
Reviewed in India on May 13, 2019
Verified Purchase
want to know the mind of people who can get affected later by a deadly genetic, dominant disease, read it
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L Bessant
5.0 out of 5 stars Brilliant.
Reviewed in the United Kingdom on June 18, 2015
Verified Purchase
This book is a must read for anybody interested in the phenomenon of living at risk for an inherited genetic disease. Not only does it describe in detail the process of developing a test for the subject disease (Huntingtons), it also delves into the social and psychological aspects of it. Brilliant.
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Chartered Librarian
1.0 out of 5 stars Stolen book
Reviewed in the United Kingdom on August 5, 2018
Verified Purchase
Yes the book arrived but it was obviously stolen from a library in the USA. It came complete with date label, security tag and library stamps. Yes, somebody had tried to ink out the name of the college library. Ineffectually, as I was able to contact the Midlands College Library and establish without a doubt that the book was stolen by a reader.

A professional bookselling company would be fully aware that libraries ALWAYS use a 'DISCARD' or 'WITHDRAWN' on ex-stock. As a chartered librarian I object to being on the receiving end of stolen goods.
One person found this helpful
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